解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The genera Actinobacillus, Haemophilus, and Pasteurella exhibit extensive polyphyletic branching in phylogenetic trees and do not represent coherent clusters of species. In this study, we have utilized molecular signatures identified through comparative genomic analyses in conjunction with genome based and multilocus ...
journal_title:International journal of genomics
pub_type: 杂志文章
doi:10.1155/2015/198560
更新日期:2015-01-01 00:00:00
abstract::Simple sequence repeats (SSRs) are among the most important markers for population analysis and have been widely used in plant genetic mapping and molecular breeding. Expressed sequence tag-SSR (EST-SSR) markers, located in the coding regions, are potentially more efficient for QTL mapping, gene targeting, and marker-...
journal_title:International journal of genomics
pub_type: 杂志文章
doi:10.1155/2015/473028
更新日期:2015-01-01 00:00:00
abstract::The expression level of each gene is controlled by its regulatory regions, which determine the precise regulation in a tissue-specific manner, according to the developmental stage of the body and the necessity of a response to external stimuli. Nucleotide substitutions in regulatory gene regions may modify the affinit...
journal_title:International journal of genomics
pub_type: 杂志文章
doi:10.1155/2015/260159
更新日期:2015-01-01 00:00:00
abstract::Background and Objectives. Chronic obstructive pulmonary disease (COPD) is a complex disease characterized by airflow limitation. Although airway inflammation and oxidative stress are known to be important in the pathogenesis of COPD, the mechanism underlying airflow obstruction is not fully understood. Gene expressio...
journal_title:International journal of genomics
pub_type: 杂志文章
doi:10.1155/2015/206937
更新日期:2015-01-01 00:00:00
abstract::Currently, protein interaction of Homo sapiens nucleotide binding domain (NBD) of heat shock 70 kDa protein (PDB: 1HJO) with p53 motif remains to be elucidated. The NBD-p53 motif complex enhances the p53 stabilization, thereby increasing the tumor suppression activity in cancer treatment. Therefore, we identified the ...
journal_title:International journal of genomics
pub_type: 杂志文章
doi:10.1155/2015/391293
更新日期:2015-01-01 00:00:00
abstract::Determining protein-protein interaction (PPI) in biological systems is of considerable importance, and prediction of PPI has become a popular research area. Although different classifiers have been developed for PPI prediction, no single classifier seems to be able to predict PPI with high confidence. We postulated th...
journal_title:International journal of genomics
pub_type: 杂志文章
doi:10.1155/2015/608042
更新日期:2015-01-01 00:00:00
abstract::Cancer is a multistep process characterized by various and different genetic lesions which cause the transformation of normal cells into tumor cells. To preserve the genomic integrity, eukaryotic cells need a complex DNA damage/repair response network of signaling pathways, involving many proteins, able to induce cell...
journal_title:International journal of genomics
pub_type: 杂志文章,评审
doi:10.1155/2014/820248
更新日期:2014-01-01 00:00:00
abstract::Deep-sea fishes provide a unique opportunity to study the physiology and evolutionary adaptation to extreme environments. We carried out a high throughput sequencing analysis on a 454 GS-FLX titanium plate using unnormalized cDNA libraries from six tissues of A. carbo. Assemblage and annotations were performed by Newb...
journal_title:International journal of genomics
pub_type: 杂志文章
doi:10.1155/2014/267482
更新日期:2014-01-01 00:00:00
abstract::Pseudomonas aeruginosa PGPR2 is a mung bean rhizosphere strain that produces secondary metabolites and hydrolytic enzymes contributing to excellent antifungal activity against Macrophomina phaseolina, one of the prevalent fungal pathogens of mung bean. Genome sequencing was performed using the Ion Torrent Personal Gen...
journal_title:International journal of genomics
pub_type: 杂志文章
doi:10.1155/2014/123058
更新日期:2014-01-01 00:00:00
abstract::The yellow color of inner leaves in Chinese cabbage depends on its lutein and carotene content. To identify responsible genes for yellow pigmentation in leaves, the transcriptome profiles of white (Kenshin) and yellow leaves (Wheessen) were examined using the Br300K oligomeric chip in Chinese cabbage. In yellow leaves...
journal_title:International journal of genomics
pub_type: 杂志文章
doi:10.1155/2014/204969
更新日期:2014-01-01 00:00:00
abstract::Severe gastroenteritis and foodborne illness caused by Noroviruses (NoVs) during the winter are a worldwide phenomenon. Vulnerable populations including young children and elderly and immunocompromised people often require hospitalization and may die. However, no efficient vaccine for NoVs exists because of their vari...
journal_title:International journal of genomics
pub_type: 杂志文章
doi:10.1155/2013/456356
更新日期:2013-01-01 00:00:00
abstract::Calmodulin II (CALM2) gene polymorphism might be responsible for the variation in the left ventricular mass amongst healthy individuals. The aim was to evaluate the correlation between left ventricular mass (LVM) and g.474955027G>A (rs7565161) polymorphism adjacent to the CALM2 gene. Healthy Polish newborns (n = 206) ...
journal_title:International journal of genomics
pub_type: 杂志文章
doi:10.1155/2013/410407
更新日期:2013-01-01 00:00:00
abstract::We characterized the male-specific region on the Y chromosome of rainbow trout, which contains both sdY (the sex-determining gene) and the male-specific genetic marker, OmyY1. Several clones containing the OmyY1 marker were screened from a BAC library from a YY clonal line and found to be part of an 800 kb BAC contig....
journal_title:International journal of genomics
pub_type: 杂志文章
doi:10.1155/2013/261730
更新日期:2013-01-01 00:00:00
abstract::The Gene Ontology (GO) provides a resource for consistent annotation of genes and gene products that is extensively used by numerous large public repositories. The GO is constructed of three subontologies describing the cellular component of action, molecular function, and overall biological process of a gene or gene ...
journal_title:International journal of genomics
pub_type: 杂志文章
doi:10.1155/2013/594528
更新日期:2013-01-01 00:00:00
abstract::Insulin resistance has a central role in the pathogenesis of several metabolic diseases, including type 2 diabetes, obesity, glucose intolerance, metabolic syndrome, atherosclerosis, and cardiovascular diseases. Insulin resistance and related traits are likely to be caused by abnormalities in the genes encoding for pr...
journal_title:International journal of genomics
pub_type: 杂志文章
doi:10.1155/2013/376454
更新日期:2013-01-01 00:00:00
abstract::In general, mutation frequencies are context-dependent: specific adjacent nucleotides may influence the probability to observe a specific type of mutation in a genome. Recently, several hypermutable motifs were identified in the human genome. Namely, there is an increased frequency of T>C mutations in the second posit...
journal_title:International journal of genomics
pub_type: 杂志文章
doi:10.1155/2013/173616
更新日期:2013-01-01 00:00:00